Hey Brad

Sakon Nakhon is a one hour flight from Bangkok. Ten hours by bus. It's a one hour drive to the Mekong river and the Lao border.

I can make some travel suggestions once I know the 'when & how many days.'  High season avoid massive tourist buses. Huge crowds and waiting in line is not my favorite tourist activity.  In Bangkok I'd suggest a 1,000 baht per day hotel near Patpong, take a canal tour, visit the palace, Wat Arun, and watch  kickboxing,and see a cabaret show and of course walk through Patpong.

I do recommend checking vaccinations. Not required, but I do recommend hepatitis vaccinations. 

High season prices tend to rise. Thai friend of mine in Bangkok is a driver for hire. in case you're interested, he can help you with planning etc

Not a big fan of Phuket. Overcrowded, I'd choose a less popular, yet serene destination 

สกลนคร Sakon Nakhon